10041
Fluka
Amphotericin B from Streptomyces sp.
BioChemika, for cell biology, powder, yellow
| Synonym: | Fungizone |
| CAS Number: | 1397-89-3 |
| Linear Formula: | C47H73NO17 |
| Molecular Weight: | 924.08 |
| Beilstein Registry Number: | 78342 |
| EC Number: | 215-742-2 |
| MDL number: | MFCD00877763 |
Description
| Application | Recommended for antifungal use in cell culture media at 2.5 mg/L. Stable at 37 °C for 3 days. |
| Biochem/physiol Actions | Polyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out. Antimicrobial spectrum: fungi and yeast. |
| Other Notes | Inhibits the growth of fungi and yeast, review1,2 |
Properties
| grade | for cell biology |
| product line | BioChemika |
| form | powder |
| composition | amphotericin B, ~45% |
| sodium deoxycholate, ~35% | |
| sodium phosphate, ~20% | |
| color | yellow |
| suitability | cell culture tested |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | BU2625000 |
References
| Cited Reference | 1. R.W. Holz Antibiotics (N.Y.) 5, 313, (1979) |
2. G. Medoff et al. Annu. Rev. Pharmacol. Toxicol. 23, 303, (1983) Abstract | |
| reference | Perlman, D., Use of antibiotics in cell culture media. Meth. Enzymol. LVIII, 112, (1979) |
| Merck | Merck 13,590 |
| Beilstein | Beil. 18,V,10,525 |
